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PACMA 31
  • 品牌:MedKoo
  • 產(chǎn)地:美國
  • 貨號:531394
  • cas:1401089-31-3
  • 發(fā)布日期: 2022-07-20
  • 更新日期: 2024-08-12
產(chǎn)品詳請
產(chǎn)地 美國
品牌 MedKoo
貨號 531394
用途 This product is for research use only, not for human or veterinary use.
包裝規(guī)格 5.0mg; 10.0mg; 25.0mg; 50.0mg; 100.0mg; 200.0mg; 500.0mg; 1.0g;
CAS編號 1401089-31-3
純度 >98%%
是否進口

Description: PACMA 31 is an orally bioavailable, selective inhibitor (IC50 = 10 μM) of protein disulfide isomerase (PDI), an endoplasmic reticulum protein that regulates oxidative protein folding by catalyzing the breakage and reformation of disulfide bonds. PDI is upregulated in ovarian, and several other cancers. PACMA 31 dose dependently inhibits proliferation of OVCAR-8 in culture and in a tumor xenograft model.

Name: PACMA 31
CAS#: 1401089-31-3
Chemical Formula: C21H22N2O6S
Exact Mass: 430.1199
Molecular Weight: 430.475
Elemental Analysis: C, 58.59; H, 5.15; N, 6.51; O, 22.30; S, 7.45

Synonym: PACMA 31; PACMA31; PACMA-31;

IUPAC/Chemical Name: N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycyl-glycine ethyl ester

InChi Key: AHOOZADJPNUFOQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H22N2O6S/c1-5-18(24)23(15-10-9-14(27-3)12-16(15)28-4)20(17-8-7-11-30-17)21(26)22-13-19(25)29-6-2/h1,7-12,20H,6,13H2,2-4H3,(H,22,26)

SMILES Code: O=C(OCC)CNC(C(C1=CC=CS1)N(C2=CC=C(OC)C=C2OC)C(C#C)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001